contains Quatrefolic®, the best absorptive, biologically active form of folic acid
- 5-MTHF bound to glucosamine salt (Quatrefolic®)
- optimal absorption and efficacy
- supports homocysteine metabolism
- essential for normal cell division
- good for memory and mood
- important before and during pregnancy
Most folic acid supplements contain the synthetic form of pteroyl monoglutamic acid , which hardly occurs in the diet and is the most oxidized form of folate. A problem with pteroylmonoglutamic acid is that in a relatively large group of people the conversion to 5-methyltetrahydrofolate (5-MTHF) progresses with difficulty. That problem can now be circumvented by taking a supplement with 'ready-to-eat' 5-MTHF : Quatrefolic ® .
About folic acid, folate, 5-MTHF, Quatrefolic ®
Folic acid (also called vitamin B11 or vitamin B9 in Germany and the US) occurs in foods as different forms of folate, including the most biologically active form 5-methyltetrahydrofolate (5-MTHF). This is the body's own form in which folate circulates in the blood. Other forms of folate and folic acid must first be converted by the body into 5-MTHF. In addition, a supplement with 'regular' folic acid in contrast to 5-MTHF can lead to a high blood level of non-metabolised folic acid, which is possibly undesirable. Folic acid can also not pass the blood-brain barrier and 5-MTHF can do this.
In the past, it has been difficult to actively incorporate folate into a supplement because of its instability. The Italian developer Gnosis has succeeded in stabilizing the folate form by binding it to a glucosamine salt (from a vegetable source). This resulted in Quatrefolic® , also called the 'fourth generation folate' because of its superior bioavailability compared to previous sources of folate or folic acid. Quatrefolic is also much more soluble in water than 5-MTHF calcium salt. As a result, it is easier to be absorbed by the cells in the intestinal wall, which explains the higher bioavailability of Quatrefolic.
Quatrefolic® is a patented product and a registered trademark of Gnosis from Italy.