The intake of high doses of St. John's wort may cause photosensitivity. These reactions are dose-dependent. The amount of 2000? G hypericin daily limit. Do not take along with: anticoagulants, cyclosporine, theophylline or digoxin. Caution is advised when taken with antidepressants. Consult your doctor with concomitant intake of St John's wort and other drugs. This product can affect the way medicines work.